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Biomedical Science and Research Journals | Negative Impact of Obesity on Dialysis Efficiency: A Prospective Cohort on Lebanese CKD Patients

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  Negative Impact of Obesity on Dialysis Efficiency: A Prospective Cohort on Lebanese CKD Patients Abstract Background:  Obesity is considered as a risk factor in chronic kidney disease (CKD), as it may worsen renal complications and progress to advanced stages of the disease. Aims: To investigate whether the efficacy of dialysis is affected in obese CKD patients. Methods:  we followed the main biological factors in dialysis patients for six months. Patients were grouped based on their sexes and body mass indexes (obese, or normal-weighted) and blood samples measurements were performed before and after dialysis. Results:  The elimination of creatinine and urea by dialysis is more significant in normal-weighted than obese women. Elimination of potassium and sodium have tendency to be also more effective in normal-weighted women. No significant differences were found between normal-weighted and obese men regarding creatinine, urea, potassium, and sodium elimination. However, parathyroid
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Biomedical Science and Research Journals | Increased Serum Glucose is not a Covid-19 Mortality Predictor in Elderly Patients

  Increased Serum Glucose is not a Covid-19 Mortality Predictor in Elderly Patients Abstract COVID-19 is causing a current pandemic with high mortality, in which older age is an important risk factor. Few studies have examined whether risk factors for death by COVID-19 are similar in elderly and younger patients. We reviewed electronic hospital records of all consecutive adult patients admitted and analyzed reported COVID-19 mortality risk factors stratified by age group (under 60 vs. 60 and over). In univariate analyses admission date, sex, age, oxygen saturation, hyperglycemia (defined as admission glucose>180mg/dl) and lactate dehydrogenase were associated with COVID-19 mortality in younger patients, while only sex, oxygen saturation and lactate dehydrogenase were associated with mortality in the elderly. Mortality for younger subjects without hyperglycemia was 39.1%, while it was 66.7% in for younger subjects with hyperglycemia, similar to the mortality in the 60 and over age gr
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Biomedical Science and Research Journals | Methamphetamine-Associated Cardiomyopathy: A Looming Epidemic for A New Generation

  Methamphetamine-Associated Cardiomyopathy: A Looming Epidemic for A New Generation Abstract Methamphetamine is a widely used drug of abuse associated with cardiovascular-related events and mortality as discussed in other case studies. There is limited scientific evidence describing the prevalence and presentation of cardiomyopathy due to the use of methamphetamine. Methamphetamine abuse is increasingly problematic, as it is causing early onset cardiomyopathy in generations younger than previously expected. There are few management guidelines for methamphetamine-associated cardiomyopathy (MAC). We present a unique case of a 54-yearold female arriving to the emergency department (ED) with a history of hypertension, obesity, asthma, and congestive heart failure. We made the diagnosis of dilated cardiomyopathy by echocardiogram with additional imaging in consultation with cardiology. Here we discuss epidemiology, pathophysiology, imaging, management, and other issues related to MAC. Keyw
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Biomedical Science and Research Journals | Microbiota for Healthy Ageing: The State of Art

  Microbiota for Healthy Ageing: The State of Art Abstract Human microbiota is composed by trillions of bacteria which play a crucial role in host health maintenance and disease pathogenesis and whose composition is unique in each person. Environmental conditions and dietary habits can modulate the shape of microbiota that, in turn, may contribute to mediate the effect of dietary components on health status. The development of a stable and diverse gut microbiota is essential for various host physiologic functions such as immunoregulation, pathogen prevention, energy harvest, and metabolism. Changes in microbial composition are often associated to the presence of common metabolic diseases such as obesity, type 2 diabetes, lipid disorders, metabolic syndrome. Gut microbiota composition is unique in each person and changes with age. While in adult’s microbiota is generally characterized by high biodiversity, in the elderly it becomes compositionally unstable and less diverse, a condition
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Biomedical Science and Research Journals | Discovery of a Nonspecific Precancer Screening Indicator named “Dicentric+Translocation” of the Chromosomal Aberrations

  Discovery of a Nonspecific Precancer Screening Indicator named “Dicentric+Translocation” of the Chromosomal Aberrations Abstract Background:  To search the major carcinogenic factor or explore a non - specific early- stage and rapid screening indicators of cancer. Methods:  Select 49 tumor patients and 60 healthy persons, Chromosome aberration and lymphocyte micronucleus were analyzed before radiation therapy of tumor patients. Results:  the “Dicentric + Translocation” of Chromosome 36(73.47%).The frequency of chromosome aberration and lymphocyte micronucleus were higher, especially the “Dicentric+Translocation “of chromosome aberrations (P <0.01), the frequency of double centromere chromosomes and translocation increased; the chromosome conglutination and dissolution appeared. Conclusion:  Could it be used as an early screening indicator for cancer; does it suggest that ionizing radiation is a major carcinogen? It is worthy of further study. Keywords:  Cancer screening indicators
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